This study examines the e-procurement practices for adoption, the willingness and readiness to adopt e-procurement and investigates the challenges to the adoption of e-procurement practices in Uganda’s Public Procuring and Disposing Entities-PDE’s. A quantitative and cross sectional survey was conducted using simple random sampling to select respondents from whom data was collected using self-administered questionnaires. The research enhances our understanding of e-procurement systems as the best practice technique in modern e-procurement system, an area which has been given less attention. Practical contributions are discussed. Download