The purpose of this study is to examine the firm-specific and macroeconomic determinants of financial performance with selected small and medium enterprises (SMEs) in the Upper East region of Ghana. The explanatory variables used in the study were firm size, firm liquidity, interest rate, inflation rate, and exchange rate. Financial performance, the dependent variable, was estimated by return on assets (ROA). The investigation was limited to a sample size of 36 SMEs on the client list of three Accounting Firms in the Upper East region. Data, covering a period of five years (2013-2017) was use for the analysis.
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